Impact of HLA allele-KIR partners on sexually transmitted HIV-1 infection

HLA-I/KIR genotypes influence HIV-1 disease progression and viral load, but their role in primary infection is uncertain. Inconsistent results from previous studies suggest that the inoculum size and transmission route-parenteral vs. sexual-may influence this association. We conducted a GWAS in a po...

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Published inThe Journal of infectious diseases
Main Authors Serrano-Rísquez, Carmen, Omar, Mohamed, Rallón, Norma, Benito, José Miguel, Gómez-Vidal, Amparo, Márquez, Francisco José, Alján, Martina, Rivero-Juárez, Antonio, Pérez-Valero, Ignacio, Rivero, Antonio, Sinangil, Faruk, Saulle, Irma, Biasin, Mara, Clerici, Mario, Forthal, Donald, Saéz, Maria Eugenia, Caruz, Antonio
Format Journal Article
LanguageEnglish
Published United States 29.08.2024
Subjects
HIV-1
GWAS
Sexual
KIR
MSM
HESN
MHC
Serodiscordant
HLA
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Summary:HLA-I/KIR genotypes influence HIV-1 disease progression and viral load, but their role in primary infection is uncertain. Inconsistent results from previous studies suggest that the inoculum size and transmission route-parenteral vs. sexual-may influence this association. We conducted a GWAS in a population of people living with HIV-1 and HIV-1-exposed seronegative individuals exposed to the virus through the sexual route. Our data do not support any role of the HLA/KIR system in susceptibility to sexually transmitted HIV-1 infection. The genetics basis of HIV-1 viral load and disease progression are distinct from the genetics of HIV resistance, a paradox worth exploring.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0022-1899
1537-6613
1537-6613
DOI:10.1093/infdis/jiae436