The INSPIRE-T longitudinal observational study centred on intrinsic capacity: baseline data

• Published in: The journals of gerontology. Series A, Biological sciences and medical sciences
• Main Authors: Guyonnet, Sophie, Hooper, Claudie, Cantet, Christelle, Coley, Nicola, Andrieu, Sandrine, Vellas, Bruno
• Format: Journal Article
• Language: English
• Published: United States 18.08.2025
• Subjects: aging; biomarkers; ICOPE; WHO
• ISSN: 1758-535X
• DOI: 10.1093/gerona/glaf181

The 'INStitute for Prevention' 'healthy agIng' and 'medicine Rejuvenative' 'translational' (INSPIRE-T) study is a 10-year observational study. The primary objective of which is to study trajectories of aging across lifespan from the perspective of intrinsic capacity (IC) through deep clinical and biological phenotyping. IC was assessed in the INSPIRE-T cohort stratified by age (10-year age groups) using the World Health Organisation (WHO) integrated care for older people (ICOPE) program. Biospecimens (bio-fluids, dental plaque, nasopharyngeal swabs, stools, hair follicles and skin biopsies) were also collected for biomarker studies and drug-target identification for the prediction and prevention of IC declines respectively. The INSPIRE-T baseline data is presented including demographic, health, anthropometric, lifestyle and IC characteristics of the cohort. The open cohort (ongoing recruitment) currently consists of 1109 participants with data available at baseline (61.9% female) aged from 20 to 102 years old (mean age ± standard deviation: 62.4 ± 19.0 years). The most prevalent IC abnormalities identified using ICOPE Step 1. screening appeared to be in vision (89.3%), audition (30.5%) and cognition (24.7%) in the total baseline population, whilst locomotor capacity abnormalities (5.4%) appeared to be the least frequent. Sex-specific differences were observed for the domains of psychological well-being, audition, vitality in 30-39 year olds and vision in subjects ≤ 39 years old. The ultimate goal of INSPIRE-T is to enable the identification of individuals at risk of IC declines in order to implement personalized preventive interventions to promote healthy aging.