Pathogenic Immunoglobulin A-Producing Cells in Immunoglobulin A Nephropathy

Immunoglobulin A nephropathy (IgAN) is the most prevalent primary glomerular disease worldwide and it remains a leading cause of kidney failure. Clinical manifestations of IgA are exacerbated by infections, and emerging data suggest that aberrant mucosal immune responses are important contributors t...

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Bibliographic Details
Published inJournal of clinical medicine Vol. 13; no. 17; p. 5255
Main Authors Makita, Yuko, Reich, Heather N.
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 05.09.2024
Subjects
Antigens
Biopsy
Bone marrow
Dendritic cells
Disease
Hypotheses
Immunoglobulins
Pathogenesis
Regional differences
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Summary:Immunoglobulin A nephropathy (IgAN) is the most prevalent primary glomerular disease worldwide and it remains a leading cause of kidney failure. Clinical manifestations of IgA are exacerbated by infections, and emerging data suggest that aberrant mucosal immune responses are important contributors to the immunopathogenesis of this disease. However, the exact stimuli, location and mechanism of nephritis-inducing IgA production remains unclear. In this focused review we explore recent developments in our understanding of the contribution of the mucosal immune system and mucosal-derived IgA-producing cells to the development of IgAN.
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ISSN:2077-0383
2077-0383
DOI:10.3390/jcm13175255