PSVIII-15 Polymorhpism of dysferlin gene in chickens

• Published in: Journal of animal science Vol. 97; no. Supplement_3; p. 272
• Main Authors: Krutikova, Anna, Plemyashov, Kirill, Dementeva, Natalia
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 05.12.2019
• Subjects: POSTER PRESENTATIONS
• ISSN: 0021-8812; 1525-3163
• DOI: 10.1093/jas/skz258.552

Abstract Dysferlin is associated with the formation of the muscle membrane, is involved in the repair of the muscle membrane and the regulation of myoblast fusion. In humans, mutations in the dysferlin gene lead to various types of muscle pathologies. The effect of dysferlin on the formation of muscle structures was detected in the early stages of embryonic development. We have suggested that mutations in the dysferlin gene in chickens can have a negative effect on the formation of muscle mass and meat traits of chickens. SNP rs16455118 was studied on chickens of different breeds and hybrids of broilers and layers. Body weight was controlled in 7, 49 and 330 days. Layers were used as a contrast. Standard indicators of egg traits (age of the first egg laying, egg production for 6 months, egg weight) were studied. SNP rs16455118 leads to the replacement of adenine by cytosine in the intron of the dysferlin gene. The GWAS method was used. As a result, the association of SNP in the dysferlin gene with meat traits in chickens was not found. But a statistically significant association of certain genotypes with egg trait in Russian white chickens was determined. Chickens with the AA and AC genotypes had more eggs compared to their peers with the SS genotype during the reference period. The difference was 10 eggs an average of (P ≤ 0.05). Project number: AAAA-A18-118021590138-1