P18 Glutaminolysis and Steatosis to Steatohepatitis Transition: Role of Glutaminase

• Published in: The American journal of gastroenterology Vol. 118; no. 9S; p. S13
• Main Authors: García-Fernández, Vanessa, Gómez, Antonio Gil, Rojas, Ángela, Muñoz-Hernández, Rocío, Gato, Sheila, Montero-Vallejo, Rocío, Gallego-Durán, Rocío, Maya-Miles, Douglas, Rico, María del Carmen, Ampuero, Javier, Romero-Gómez, Manuel
• Format: Journal Article
• Language: English
• Published: New York Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins 01.09.2023
• Subjects: Ammonia; Biopsy; Gastroenterology; Liver cirrhosis; Multivariate analysis; Protein expression

Gls gene expression, Gls activity and protein expression were assessed by qPCR, fluorometric and IHC assays. The length of a microsatellite in the promoter region of GLS was assessed by capillary electrophoresis (long allele>14 GCA repeats). Results: Hepatic Gls expression was found to increase a...