S1527 Adrenal Dysfunction Does Not Predict Increased Rates of Portal Hypertension-Related Decompensation in Outpatients With Decompensated Cirrhosis

• Published in: The American journal of gastroenterology Vol. 118; no. 10S; pp. S1156 - S1157
• Main Authors: Geng, Calvin X., Kadiyala, Jagannath, Siragy, Helmy, Henry, Zachary, Wentworth, Brian J.
• Format: Journal Article
• Language: English
• Published: New York Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins 01.10.2023
• Subjects: Clinical outcomes; Comorbidity; Hormones; Hospitalization; Hypertension; Liver cirrhosis; Mortality; Regression analysis
• ISSN: 0002-9270; 1572-0241
• DOI: 10.14309/01.ajg.0000955748.72347.1b

Baseline characteristics including age, sex, comorbidity index, and MELD were similar (Table 1). Analysis of Patients with and without Adrenal Dysfunction No Adrenal Dysfunction Adrenal Dysfunction Selected Demographics n=41 n=18 P-value  Age (years) 57.8 (11.6) 60.5 (9.3) 0.39  Female (%) 22 (53.7) 9 (50.0) 1.00  MELD Score 12.8 (3.8) 13.2 (3.4) 0.71  CCI 2.2 (1.4) 2.1 (1.3) 0.68  Cortisol at 0 minutes (µg/dL) 7.1 (3.7) 9.5 (4.3) 0.03*  Cortisol at 60 minutes (µg/dL) 19.4 (4.2) 17.0 (3.9) 0.04*  ∆Cortisol (µg/dL) 12.3 (2.8) 7.5 (1.2) < 0.001* Outcomes  Transplant (%) 2 (4.9) 2 (11.1) 0.75  Mortality (%) 1 (2.4) 0 (0) 1.00  pHTN Hospitalizations (%) 8 (19.5) 3 (16.7) 1.00  Non-pHTN Hospitalizations (%) 8 (19.5) 3 (16.7) 1.00  Decompensation (%) 28 (68.3) 15 (83.3) 0.38 Multivariate Analysis for pHTN-related Decompensation Independent Variable OR 95% CI P-value  Age 0.85 0.74 – 0.95 0.01*  MELD Score 1.05 0.87 – 1.26 0.62  CCI 3.27 1.29 – 11.0 0.03*  Adrenal Dysfunction 3.95 0.94 – 21.9 0.08 AD: Charlson Comorbidity Index; OR: odds ratio; CI: confidence interval; Continuous variables presented as means (SD).