A New Prenylated Flavone fromArctocarpus champedenInhibits the K+-Dependent Amino Acid Transport inBombyx moriMidgut

The effect of some flavonoids on the K+-dependent and K+-independent leucine uptake into brush border membrane vesicles fromBombyx morilarval midgut was investigated. Among the compounds tested, cyclochampedol, recently purified fromArtocarpus champeden,was able to inhibit in micromolar range the le...

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Published inBiochemical and biophysical research communications Vol. 244; no. 2; pp. 445 - 448
Main Authors Parenti, Paolo, Pizzigoni, Alessandro, Hanozet, Giorgio, Hakim, Euis Holisotan, Makmur, Lukman, Achmad, Sjamsul Arifin, Giordana, Barbara
Format Journal Article
LanguageEnglish
Published Elsevier Inc 17.03.1998
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Summary:The effect of some flavonoids on the K+-dependent and K+-independent leucine uptake into brush border membrane vesicles fromBombyx morilarval midgut was investigated. Among the compounds tested, cyclochampedol, recently purified fromArtocarpus champeden,was able to inhibit in micromolar range the leucine transport. The inhibition occurred both in the absence and in the presence of potassium and was not affected by leucine concentration. The apparentKiwas 0.25 mM. Cyclochampedol represents the first non-competitive inhibitor of an amino acid transport system in Lepidoptera. The relevance of this result is discussed.
ISSN:0006-291X
1090-2104
DOI:10.1006/bbrc.1998.8299