S230 Risk Factors for Fecal Microbiota Transplant Failure and Their Utility in Predicting FMT Outcomes: A Nationwide Retrospective Study

• Published in: The American journal of gastroenterology Vol. 118; no. 10S; pp. S172 - S173
• Main Authors: Hussan, Hisham, Al-Juburi, Saleh, Romeo, Sean K., Ali, Mohamed, Shamseddeen, Hazem, Coe, Kelci, Chiang, ChienWei, Reed, Erica
• Format: Journal Article
• Language: English
• Published: New York Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins 01.10.2023
• Subjects: Colonoscopy; Gastrointestinal surgery; Inflammatory bowel disease; Microbiota; Success
• ISSN: 0002-9270; 1572-0241
• DOI: 10.14309/01.ajg.0000950560.69857.38

A forward selection method was conducted, which took into consideration adjusted R2, AIC, and the log-likelihood to determine the best model fit. In the final MLR model, age [odds ratio (OR) 1.022; 95%CI,1.01-1.03], male sex (OR 0.65; 95% CI, 0.45-0.94), IBD (OR 2.92; 95% CI, 2.01-4.2), and FMT delivery method (OR 3.03; 95%CI, 2.15-4.28) were predictive of future FMT outcomes. Odds Ratio and Univariate Analysis Comparing FMT Failure vs FMT Success FMT Failure (n=207) FMT Success (n=919) P-Value Odd Ratio 95% CI Median or n IQR or % Median or n IQR or % Age (years) 64 50-78 58 47-67 < .0001 1.02 1.01 - 1.03 Sex < .0001 1.91 1.36 - 2.68  Male 53 26% 365 40%  Female 154 74% 554 60% Charlson Comorbidity Score 3 1 - 4.0 2 1 - 3.0 < .0001 1.27 1.1 - 1.4 IBD 159 77% 396 43% < .0001 4.37 3.09 - 6.2 Immunosuppression 15 7% 53 6% 0.42 1.28 0.7 - 2.3  HIV 0 0% 2 0% 1  Immunosuppression medications 9 4% 30 3% 0.44 1.34 0.63 - 2.88  Transplant 7 3% 32 3% 0.94 0.97 0.42 - 2.23 BMI (kg/m2) 0.67  19-24 8 4% 26 3%  25-29 9 4% 36 4%  30-39 30 14% 148 16%  40 or greater 10 5% 59 6% Pregnant within 12 months Prior to FMT 1 0% 10 1% 0.7 0.44 0.05 - 3.47 Bariatric Surgery prior to FMT 4 2% 83 9% 0.0001 0.2 0.07 - 0.55 Active Malignancy 53 26% 296 32% 0.06 0.72 0.52 - 1.02 Abdominal Surgery prior to FMT 10 5% 101 11% 0.007 0.41 0.21 - 0.80 CDI Number prior to FMT 0.71 1.08 0.7 - 1.66  1 142 69% 229 25%  >1 47 23% 70 8% FMT Delivery Method < .0001 4.4 3.2 - 6.1  Colonoscopy 138 67% 286 31%  Other (e.g., oral or through enteroscopy) 69 33% 633 69% Hospitalization for FMT < .0001 8.18 5.73 - 11.7  Yes 47 23% 649 71%  No 160 77% 270 29% Continuous variables represented as median/IQR and students Ttest utilized Chisq test / Fischers exact test used for categorical data Author Notes *Presenter