Transdermal fentanyl therapy for pains in children withinfantile neuronal ceroid lipofuscinosis

We used infantile neuronal ceroid lipofuscinosis (INCL), in which deterioration of the central nervous system is extremely rapid, to study constant release of an opioid for pains of central origin in a metabolic disease. The effect of a transdermal fentanyl patch was studied in five children with IN...

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Published inEuropean journal of paediatric neurology Vol. 5; pp. 175 - 177
Main Authors Mannerkoski, Minna K., Heiskala, Hannu J., Santavuori, Pirkko R.A., Pouttu, Jukka A.
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 2001
Subjects
INCL
Pain
Transdermal fentanyl
INCL
Transdermal fentanyl
Pain
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Summary:We used infantile neuronal ceroid lipofuscinosis (INCL), in which deterioration of the central nervous system is extremely rapid, to study constant release of an opioid for pains of central origin in a metabolic disease. The effect of a transdermal fentanyl patch was studied in five children with INCL. In two of them, measurements of 17 fentanyl serum concentrations and also visual analogue pain scale were obtained during a 15-day study period. Low doses of transdermal fentanyl usually provided good pain relief for the first two days, but not for the third day, of the three-day patch change interval. Pain relief of this type seems mandatory for pains mostly of central origin.
ISSN:1090-3798
1532-2130
DOI:10.1053/ejpn.2000.0457