Diuretics in treatment of patients with arterial hypertension

Since all cardiovascular risk factors contribute to coronary artery disease in patients with arterial hypertension, they should all be considered in the management of this disease process. Thiazides diuretics when used at high doses, negatively impact lipid and glucose metabolism. These findings hav...

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Bibliographic Details
Published inSistemnye gipertenzii (Online) Vol. 6; no. 4; pp. 9 - 12
Main Authors Irina Evgen'evna Chazova, Lyudmila Gennadievna Ratova
Format Journal Article
LanguageRussian
Published IP Morozov P.V 15.12.2009
Subjects
arterial hypertension
hydrochlorothiazide
thiazides diuretics
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Summary:Since all cardiovascular risk factors contribute to coronary artery disease in patients with arterial hypertension, they should all be considered in the management of this disease process. Thiazides diuretics when used at high doses, negatively impact lipid and glucose metabolism. These findings have resulted in decreased use of diuretics in favor of newer agents such as ACE inhibitors and calcium antagonists. However, recent data have demonstrated that when used at low doses (6.25 or 25 mg of hydrochlorothiazide), diuretics lack significant metabolic side effects while bringing about significant reductions in blood pressure. Thus, at these doses, hydrochlorothiazide is a useful drug in the treatment of hypertension, both as monotherapy and in combination therapy.
ISSN:2075-082X
2542-2189
DOI:10.26442/SG33065