Synthesis of a 188Re-HEDP complex using carrier-free 188Re and a study of its stability and biological distribution

Labeling of disodium dihydrogen 1-hydroxyethane-1,1-diphosphonate (HEDP) with 188 Re was studied. Stannous chloride was used as a reducing agent for the reduction of 188 ReO 4 − . The dependence of the yield of 188 Re-HEDP complex upon the HEDP concentration, tin(II) content, reaction time, amount o...

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Published inRadiochemistry (New York, N.Y.) Vol. 53; no. 4; pp. 415 - 420
Main Authors Nassar, M. Y., El-Kolaly, M. T., Mahran, M. R. H.
Format Journal Article
LanguageEnglish
Published Dordrecht SP MAIK Nauka/Interperiodica 01.08.2011
Subjects
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Nuclear Chemistry
HEDP
stability
rhenium-188
bone uptake
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Summary:Labeling of disodium dihydrogen 1-hydroxyethane-1,1-diphosphonate (HEDP) with 188 Re was studied. Stannous chloride was used as a reducing agent for the reduction of 188 ReO 4 − . The dependence of the yield of 188 Re-HEDP complex upon the HEDP concentration, tin(II) content, reaction time, amount of antioxidant, pH, reaction temperature, and presence of carrier was examined. The optimum conditions ensuring high labeling yield of 188 Re-HEDP complex (91.0% with carrier-free Re and 96.5% with carrier-added Re) are as follows: 15 mg of HEDP, 2 mg of Sn(II), 4 mg of ascorbic acid, pH 1.2, 100°C, 10 min. The amount of the carrier added is 200 μg of KReO 4 . The 188 Re-HEDP complex prepared at 100°C is more stable than that prepared at 30°C, and the carrier-added 188 Re-HEDP complex is more stable than the no-carrier-added complex.
ISSN:1066-3622
1608-3288
DOI:10.1134/S1066362211040151