1H NMR detection of small molecules in human urine with a deep cavitand synthetic receptor

A water-soluble deep cavitand recognized alkylammonium salts, including the drug amantadine hydrochloride, in spiked samples of human urine. The signals of the guests are detected by (1)H NMR upfield of 0 ppm and so occur in a spectroscopic window that is outside of the normal region and distinct fr...

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Bibliographic Details
Published inAnalyst (London) Vol. 138; no. 4; pp. 1008 - 1010
Main Authors Ryan, Daniel A, Rebek, Jr, Julius
Format Journal Article
LanguageEnglish
Published England 21.02.2013
Subjects
Amantadine - urine
Ethers, Cyclic - chemistry
Humans
Hydrogen
Magnetic Resonance Spectroscopy - methods
Receptors, Artificial - chemistry
Resorcinols - chemistry
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Summary:A water-soluble deep cavitand recognized alkylammonium salts, including the drug amantadine hydrochloride, in spiked samples of human urine. The signals of the guests are detected by (1)H NMR upfield of 0 ppm and so occur in a spectroscopic window that is outside of the normal region and distinct from the signals of the biofluid components.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0003-2654
1364-5528
DOI:10.1039/c2an36635e