A Case of Glycogen-rich Clear Cell Carcinoma in the Breast of a Young Female
Glycogen-rich clear cell carcinoma (GRCC) of the breast is a rare variant of primary breast carcinoma that is diagnosed when more than 90% of the tumor cells is polygonal cells with a clear cytoplasm containing abundant water-soluble glycogen. A case of GRCC in a 27-year-old Japanese woman is report...
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Published in | Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) Vol. 74; no. 11; pp. 2992 - 2996 |
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Main Authors | , |
Format | Journal Article |
Language | English Japanese |
Published |
Japan Surgical Association
2013
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Subjects | |
Online Access | Get full text |
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Summary: | Glycogen-rich clear cell carcinoma (GRCC) of the breast is a rare variant of primary breast carcinoma that is diagnosed when more than 90% of the tumor cells is polygonal cells with a clear cytoplasm containing abundant water-soluble glycogen. A case of GRCC in a 27-year-old Japanese woman is reported. She had noticed a small lump, 8 mm in diameter, in the upper inner quadrant of the left breast. On mammography and ultrasound, a category 3 tumor was found. However, the fine needle aspiration cytology was benign. Six months later, the tumor size increased to 15 mm. An extirpation was performed. On histology, the tumor was composed of sheets or nests of clear cells with optically clear cytoplasm and distinct cell borders. The PAS stain revealed abundant PAS-positive cells, and diastase digestive material in the cytoplasm. On immunohistochemistry, the tumor cells were positive for ER and PR, but negative for HER2. The patient is on hormone therapy (an LH-RH agonist and Tamoxifen) and is being followed. |
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ISSN: | 1345-2843 1882-5133 |
DOI: | 10.3919/jjsa.74.2992 |