A Case of Glycogen-rich Clear Cell Carcinoma in the Breast of a Young Female

Glycogen-rich clear cell carcinoma (GRCC) of the breast is a rare variant of primary breast carcinoma that is diagnosed when more than 90% of the tumor cells is polygonal cells with a clear cytoplasm containing abundant water-soluble glycogen. A case of GRCC in a 27-year-old Japanese woman is report...

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Bibliographic Details
Published inNihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) Vol. 74; no. 11; pp. 2992 - 2996
Main Authors ISHII, Seiichiro, SUGIURA, Hitoshi
Format Journal Article
LanguageEnglish
Japanese
Published Japan Surgical Association 2013
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Summary:Glycogen-rich clear cell carcinoma (GRCC) of the breast is a rare variant of primary breast carcinoma that is diagnosed when more than 90% of the tumor cells is polygonal cells with a clear cytoplasm containing abundant water-soluble glycogen. A case of GRCC in a 27-year-old Japanese woman is reported. She had noticed a small lump, 8 mm in diameter, in the upper inner quadrant of the left breast. On mammography and ultrasound, a category 3 tumor was found. However, the fine needle aspiration cytology was benign. Six months later, the tumor size increased to 15 mm. An extirpation was performed. On histology, the tumor was composed of sheets or nests of clear cells with optically clear cytoplasm and distinct cell borders. The PAS stain revealed abundant PAS-positive cells, and diastase digestive material in the cytoplasm. On immunohistochemistry, the tumor cells were positive for ER and PR, but negative for HER2. The patient is on hormone therapy (an LH-RH agonist and Tamoxifen) and is being followed.
ISSN:1345-2843
1882-5133
DOI:10.3919/jjsa.74.2992