Interstitial Cells of Cajal in Deep Esophageal Leiomyoma

Gastrointestinal stromal tumors (GISTs) are potentially aggressive mesenchymal neoplasms with spindle cell, epithelioid, or mixed morphology. They typically express CD117, DOG1, and CD34 and can be diffusely and strongly positive for h-caldesmon. Leiomyomas are benign smooth muscle neoplasms that ca...

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Bibliographic Details
Published inInternational journal of surgical pathology Vol. 25; no. 1; p. 51
Main Authors Hallin, Magnus, Mudan, Satvinder, Thway, Khin
Format Journal Article
LanguageEnglish
Published United States 01.02.2017
Subjects
Biomarkers, Tumor - analysis
Diagnosis, Differential
Esophageal Neoplasms - diagnosis
Esophageal Neoplasms - pathology
Gastrointestinal Stromal Tumors - diagnosis
Gastrointestinal Stromal Tumors - pathology
Humans
Immunohistochemistry
Interstitial Cells of Cajal - pathology
Leiomyoma - diagnosis
Leiomyoma - pathology
gastrointestinal tract
pathology
sarcoma
gastrointestinal stromal tumor
DOG1
CD117
interstitial cells of Cajal
leiomyoma
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Summary:Gastrointestinal stromal tumors (GISTs) are potentially aggressive mesenchymal neoplasms with spindle cell, epithelioid, or mixed morphology. They typically express CD117, DOG1, and CD34 and can be diffusely and strongly positive for h-caldesmon. Leiomyomas are benign smooth muscle neoplasms that can arise in a variety of visceral and soft tissue sites, including the gastrointestinal tract. We illustrate a case of a neoplasm of the gastroesophageal junction that was clinically suspected to be a GIST. Histology showed a tumor composed of ovoid and spindle cells arranged in short intersecting fascicles, which was positive for desmin, smooth muscle actin, and h-caldesmon, with a prominent interspersed subpopulation of CD117- and DOG1-positive elongated or dendritic-like cells. These features were of leiomyoma with entrapped interstitial cells of Cajal (ICC). The recognition of possible entrapment of ICC in leiomyomas as a potential mimic of GIST is important for correct treatment and prognostication.
ISSN:1940-2465
DOI:10.1177/1066896916660197