Metabolic engineering for single-cell protein production from renewable feedstocks and its applications

Proteins are indispensable for maintaining a healthy diet and performing crucial functions in a multitude of physiological processes. The growth of the global population and the emergence of environmental concerns have significantly increased the demand for protein-rich foods such as meat and dairy...

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Bibliographic Details
Published inAdvanced Biotechnology Vol. 2; no. 4
Main Authors Zhuang, Zhoukang, Wan, Guangyu, Lu, Xiaocong, Xie, Linhai, Yu, Tao, Tang, Hongting
Format Journal Article
LanguageEnglish
Published Singapore Springer Nature Singapore 29.09.2024
Subjects
Biochemistry
Bioinformatics
Biomedical and Life Sciences
Biotechnology
Cell Biology
Genetics and Genomics
Life Sciences
Nucleic Acid Chemistry
Review
Metabolic engineering
Food proteins
Renewable material
Single-cell proteins
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Summary:Proteins are indispensable for maintaining a healthy diet and performing crucial functions in a multitude of physiological processes. The growth of the global population and the emergence of environmental concerns have significantly increased the demand for protein-rich foods such as meat and dairy products, exerting considerable pressure on global food supplies. Single-cell proteins (SCP) have emerged as a promising alternative source, characterized by their high protein content and essential amino acids, lipids, carbohydrates, nucleic acids, inorganic salts, vitamins, and trace elements. SCP offers several advantages over the traditional animal and plant proteins. These include shorter production cycles, the use of diverse raw material sources, high energy efficiency, and minimal environmental impact. This review is primarily concerned with the microbial species employed in SCP production, utilization of non-food renewable materials as a source of feedstock, and application of rational and non-rational metabolic engineering strategies to increase SCP biomass and protein content. Moreover, the current applications, production shortages, and safety concerns associated with SCP are discussed.
ISSN:2948-2801
DOI:10.1007/s44307-024-00042-8