A case of Stevens-Johnson syndrome showing initial symptoms in the oral cavity and short-term recurrence

• Published in: Japanese Journal of Oral and Maxillofacial Surgery Vol. 60; no. 3; pp. 137 - 141
• Main Authors: NAKAJIMA, Yoichiro, UENO, Takaaki, KIMURA, Yoshihiro, ITO, Yuichi, NAKAGAWA, Yasuko
• Format: Journal Article
• Language: English; Japanese
• Published: Japanese Society of Oral and Maxillofacial Surgeons 20.03.2014
• Subjects: ambroxol hydrochloride; herpes simplex virus; oral care; Stevens-Johnson syndrome; tranexamic acid
• ISSN: 0021-5163; 2186-1579
• DOI: 10.5794/jjoms.60.137

Stevens-Johnson syndrome （SJS） is a serious systemic disease mainly caused by medications. We report our experience with a case of SJS that caused primary symptoms in the mouth and relapsed a short period of time after recession of the primary symptoms. The patient was a 41-year-old man. He took medication prescribed by a local doctor and then visited our office because he became aware of an acute exacerbation of stomatitis. Ambroxol hydrochloride and tranexamic acid showed positive reactions on drug-induced lymphocyte stimulation tests. Therefore, it was presumed that these medications had caused SJS. Participation of Herpes simplex virus was suspected at the time of recurrence and the first attack. Serious or intractable stomatitis is common in our field, and it is important to take potential primary symptoms of SJS into account on clinical examinations. This case suggests that oral medical care is very important in SJS.