Effects of Polyethylene Oxide Concentration on the Size of Beads in Electrospun Beaded Nanofibers

• Published in: 东华大学学报（英文版） Vol. 31; no. 4; pp. 511 - 514
• Main Author: 张媛 李庭晓 丁辛 胡吉永 杨旭东
• Format: Journal Article
• Language: English
• Published: Key Laboratory of Textile Science & Technology, Ministry of Education of China, Donghua University, Shanghai 201620, China%College of Textiles, Donghua University, Shanghai 201620, China%Key Laboratory of Textile Science & Technology, Ministry of Education of China, Donghua University, Shanghai 201620, China 31.08.2014; College of Textiles, Donghua University, Shanghai 201620, China
• Subjects: bead size; polyethylene oxide (PEO); concentration; beaded nanofiber; electrospinning
• ISSN: 1672-5220

Embedding particle drugs in beaded nanofibers by electrospinning has been shown a potential approach to control drug release in tissue engineering. The bead size is one of the critical parameters in controlling the drug release rate. In this study,the relationship between polymer concentration and beads size was investigated. Aqueous polyethylene oxide（ PEO） solutions with different concentrations were prepared to obtain various beaded nanofibers by electrospnning. Optical microscope and scanning electron microscope（ SEM） were used to observe the variation tendency of bead size. With an increase in the polymer concentration,the diameter of fibers between beads became bigger,while the fiber uniformity improved. In addition, the polymer concentration influenced the distribution of bead diameter. Higher polymer concentration would reduce the possibility of small-sized beads formation and improve the uniformity of bead diameter. The study provides a possible way to control the size of beads,which is helpful for further research on the control of particle drug release.