Hypoglycemic, hypolipidemic and antioxidant potential of Myrcia pubipetala in an animal model of type 1 diabetes

• Published in: Acta scientiarum. Biological sciences Vol. 46; p. e71571
• Main Authors: Vieira, Bruna Maria, Golineli, Ana Luiza de Moraes, Wiggers, Brenda, Wayszceyk, Sheila, Pauleti, Nathielli Nayara, Alberton, Michele Debiasi, Delwing de Lima, Daniela, Herkenhoff, Kauê Vilmar, Dal Magro, Débora Delwing
• Format: Journal Article
• Language: English; Portuguese
• Published: Maringa Editora da Universidade Estadual de Maringá - EDUEM 02.09.2024
• Subjects: Animal models; Antioxidants; Diabetes; Diabetes mellitus (insulin dependent); Erythrocytes; Hypoglycemic agents; Myrcia; Oxidative stress; Triglycerides
• ISSN: 1679-9283; 1807-863X
• DOI: 10.4025/actascibiolsci.v46i1.71571

Myrcia genus plants, like Myrcia pubipetala, traditionally used as hypoglycemic agents, hold promise for Type 1 Diabetes Mellitus (DM1) research but need more comprehensive chemical and pharmacological investigation. This is an experimental study involving controlled administration of treatments to a group of rats to assess their effects compared with a control group, investigating the effects of M. pubipetala on alloxan-induced Type 1 Diabetes Mellitus in rats. After the induction of diabetes, the rats received the hydroalcoholic extract (HAE) or aqueous fraction (AF) (25, 50, 100, or 150 mg kg-1) of M. pubipetala, or water. The results showed that diabetic rats presented cell damage in kidneys, oxidative stress, and high levels of glucose and triglycerides in their plasma and erythrocytes. The HAE (150 mg kg-1), per se, reduced lipid and protein oxidation, and the AF (150 mg kg-1) decreased lipoperoxidation. AF (150 mg kg-1), per se, decreased triglyceride levels. Conclusion: treatment with HAE and AF reduced oxidative damage, positively modulated antioxidant defenses, and exerted hypoglycemic and hypolipidemic effects, representing a potential adjuvant treatment for diabetes.