Recherche de substances naturelles à activité thérapeutique (2)
This series of brief reviews covers the “life and work” of famous and iconic researchers who discovered major therapeutics from natural products: their life history, the circumstances of their discoveries, the molecules and their molecular, cellular and physiological mechanisms of action, and their...
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Published in | M.S. Médecine sciences Vol. 30; no. 3; pp. 319 - 328 |
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Main Authors | , , |
Format | Journal Article |
Language | French |
Published |
EDP Sciences
01.03.2014
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Online Access | Get full text |
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Summary: | This series of brief reviews covers the “life and work” of famous and iconic researchers who discovered major therapeutics from natural products: their life history, the circumstances of their discoveries, the molecules and their molecular, cellular and physiological mechanisms of action, and their biomedical applications. Dedicated to George R. Pettit, the second article reviews the life of the famous researcher, his worldwide exploration of natural products, especially of marine origin, in search of promising anticancer leads, his discovery and structural elucidation of very potent drug candidates, their synthesis and the launch of some of them on the pharmaceutical market. An extraordinary scientific career which lead George R. Pettit from exploration of Nature to state-of-the-art analytical and synthetic chemistry and from clinical trials to therapeutic successes. |
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Bibliography: | istex:8FE36877D7C7B6E63F7B4533512FD65572AE8846 ark:/67375/80W-KLMK67SW-N publisher-ID:medsci20143003p319 dkey:10.1051/medsci/20143003021 |
ISSN: | 0767-0974 1958-5381 |
DOI: | 10.1051/medsci/20143003021 |