Comparison Between Invasive Breast Cancer With Extensive Peritumoral Vascular Invasion and Inflammatory Breast Carcinoma

• Published in: American journal of clinical pathology Vol. 142; no. 3; pp. 299 - 306
• Main Authors: Manfrin, Erminia, Remo, Andrea, Pancione, Massimo, Cannizzaro, Claudia, Falsirollo, Francesca, Pollini, Giovanni Paolo, Pellini, Francesca, Molino, Annamaria, Brunelli, Matteo, Vendraminelli, Roberto, Ceccarelli, Michele, Pagnotta, Stefano Maria, Simeone, Ines, Bonetti, Franco
• Format: Journal Article
• Language: English
• Published: 01.09.2014
• ISSN: 0002-9173; 1943-7722
• DOI: 10.1309/AJCPOXKX67KRAOVM

Abstract Objectives: Extensive peritumoral neoplastic lymphovascular invasion (ePVI) is a marker of aggressiveness in invasive breast carcinoma (BC). Methods: We explored the impact of ePVI on different BC subtypes. In a total of 2,116 BCs, 91 ePVI-BCs, 70 inflammatory breast carcinomas (IBCs), and 114 casual BCs as a control group (CG-BC) were recruited. Results: Patients affected by ePVI-BC were younger, had larger tumors, higher histologic grade, elevated Ki-67 score, Her2/neu overexpressed, and more lymph node metastases compared with CG-BC (P < .001). Interestingly, only younger mean age at diagnosis differentiated patients with ePVI-BC from patients affected by IBC. ePVI-BC showed a clinical outcome intermediate between the prognoses of IBC and CG-BC. Conclusions: Results suggest that ePVI-BC and IBC may share some pathologic processes, providing a novel perspective on the heterogeneity of BC. Epidemiologic data and molecular studies on gene expression features are needed to rationally classify these tumors into their identified subtypes.