AGGREGATE SURVEILLANCE DATA OF NEONATAL THROMBOCYTOPENIA IN JAPAN

• Published in: Japanese Journal of Transfusion and Cell Therapy Vol. 56; no. 4; pp. 508 - 514
• Main Authors: Iino, Miho, Inoue, Susumu, Futakami, Yuki, Kobayashi, Hironari, Kato, Naomi, Morita, Shoji, Ishijima, Ayako, Shibata, Youichi, Mizoguti, Hideaki, Minami, Mutsuhiko
• Format: Journal Article
• Language: Japanese
• Published: The Japan Society of Transfusion Medicine and Cell Therapy 2010
• Subjects: anti-HLA antibody; anti-HPA antibody; cross-matching test; NAIT; neonatal thrombocytopenia
• ISSN: 1881-3011; 1883-0625
• DOI: 10.3925/jjtc.56.508

A surveillance program was conducted in collaboration with the members of the Platelet Granulocyte Workshop of the Japanese Society of Blood Transfusion and Cell Therapy between April 2007 and March 2009, including 66 cases with platelet count <15×104/μl. Unlike hemolytic disease of the newborn, the majority of cases occurred in the first pregnancy. Neither the mother's history of previous pregnancies or blood transfusion, nor past history was significantly correlated with the detection rate of anti-platelet antibodies. Gestational age, body weight, and platelet count of the newborn at birth were not significantly correlated with the development of intracranial bleeding of the affected newborn. The specificity of the detected antibodies was as follows: anti-HLA antibody only in 29.2%, anti-HPA antibody in 17.6%, and none in 47.9%. The cross-matching test of anti-HPA-positive sera was positive in all case. Among HPA antibody, the most frequent was HPA-4b antibodies, followed by HPA-5b antibodies.