Pharmacokinetics Of Zinc In Broiler Chickens After Single Intraingluvial Administration With Zinc Aspartate

The pharmacokinetics of zinc was investigated in broiler chickens after single crop intubation of 50 mg/kg 5% zinc aspartate suspension in 2% carboxymethyl cellulose solution. Blood serum zinc concentrations were assayed on a biochemical analyzer. The pharmacokinetics of zinc was evaluated using two...

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Published inJournal of Biomedical and Clinical Research Vol. 7; no. 2; pp. 88 - 92
Main Authors Ivanova, Sofiya L., Dimitrova, Dimitrichka J., Petrichev, Metodi H., Parvanova, Liliana I., Kalistratov, Georgi Sl, Vezenkov, Lubomir T.
Format Journal Article
LanguageEnglish
Published De Gruyter Open 01.12.2014
Subjects
chickens
pharmacokinetics
zinc aspartate
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Summary:The pharmacokinetics of zinc was investigated in broiler chickens after single crop intubation of 50 mg/kg 5% zinc aspartate suspension in 2% carboxymethyl cellulose solution. Blood serum zinc concentrations were assayed on a biochemical analyzer. The pharmacokinetics of zinc was evaluated using two approaches – compartmental method and non-compartmental analysis using pharmacokinetic software (TopFit, v. 2.0). After the intraingluvial application, zinc was rapidly absorbed (t =0.1040.02 h) by the alimentary system of birds attaining C of 63.603.94 mol/ml by hour 0.77 (compartmental method) and C =69.274.35 mol/ml by hour 0.92 h (non-compartmental method). It is characterized with a long biological half-life (t ) of 13.821.63 h (compartmental analysis) and 15.961.73 h (non-compartmental analysis) and long mean residence times (MRT) 20.122.35 h and 23.002.50 h, respectively. The distribution in blood and extracellular fluid was good as seen from Vd values 0.770.05 l/kg (compartmental analysis) and 0.650.05 l/kg (non-compartmental analysis).
ISSN:1313-9053
1313-9053
DOI:10.1515/jbcr-2015-0131