PERCUTANEOUS CLOSURE OF PATENT FORAMEN OVALE OR MEDICAL THERAPY FOR STROKE PREVENTION: A META-ANALYSIS OF RANDOMIZED TRIALS

Ischemic stroke (IS), transient ischemic attack (TIA), a composite of IS, TIA and systemic thromboembolism (STE), mortality, major bleeding, atrial fibrillation and procedural complications were the major outcomes. PFOC, compared to MT reduced the risk of ischemic stroke [Odds ratio (OR): 0.38; 95%...

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Published inJournal of the American College of Cardiology Vol. 71; no. 11; p. A1236
Main Authors Dahal, Khagendra, Yousuf, Adil, Hanna, Magdy, Sharma, Sharan, Rijal, Jharendra, Watti, Hussam, Garcia, Nelson Telles, Njoku, Augustine, Lee, Juyong, Katikaneni, Pavan, Jimenez, Enrique, Modi, Kalgi, Tandon, Neeraj
Format Journal Article
LanguageEnglish
Published New York Elsevier Inc 10.03.2018
Elsevier Limited
Subjects
Cardiac arrhythmia
Cardiology
Meta-analysis
Stroke
Thromboembolism
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Summary:Ischemic stroke (IS), transient ischemic attack (TIA), a composite of IS, TIA and systemic thromboembolism (STE), mortality, major bleeding, atrial fibrillation and procedural complications were the major outcomes. PFOC, compared to MT reduced the risk of ischemic stroke [Odds ratio (OR): 0.38; 95% confidence interval (OR): 0.17-0.88, P=0.03] and the composite outcome of ischemic stroke, TIA and systemic thromboembolism [0.49 (0.24-0.99); P=0.05].
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(18)31777-7