Synthesis and characterization of new 2-quinolone sulfonamide derivatives

A series of new 2-quinolone derivatives linked to benzene sulphonyl moieties were performed by many steps: the first step involved preparation of different coumarins (A1,A2) by condensation of different substituted phenols with ethyl acetoacetate. The compound A1 was treated with nitric acid to affo...

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Bibliographic Details
Published inBaghdad Science Journal. Vol. 13; no. 4; pp. 806 - 818
Main Authors Khalil, Muhammad Rifat Ahmad, al-Bayati, Rida Ibrahim, Ahmad, Lama Sami
Format Journal Article
LanguageArabic
English
Published Baghdad, Iraq University of Baghdad, College of Science for Women 04.12.2016
College of Science for Women, University of Baghdad
Subjects
"2-quinolones, coumarin, sulfonamide."
التخليق الكيميائي
الخواص الفيزيائية
السلفوناميدات
الكوينولونات
مقاييس الطيف
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Summary:A series of new 2-quinolone derivatives linked to benzene sulphonyl moieties were performed by many steps: the first step involved preparation of different coumarins (A1,A2) by condensation of different substituted phenols with ethyl acetoacetate. The compound A1 was treated with nitric acid to afford two isomers of nitrocoumarin derivatives (A3) and (A4). The prepared compounds (A2, A3) were treated with hydrazine hydrate to synthesize different 2-quinolone compounds (A5,A6) while the coumarin treated with different amines gave compounds (A7,A8). Then the synthesized 2-quinolone compounds (A5-A8) treated with benzene sulphonyl chloride to afford new sulfonamide derivatives (A9-A12). The synthesized compounds were characterized by FT-IR, 1H-NMR, 13C-NMR spectra and by measurement some of their physical properties.
ISSN:2078-8665
2411-7686
2411-7986
DOI:10.21123/bsj.13.4.806-818