Safety and efficacy of COVID-19 vaccines in children and adolescents with cancer

• Published in: Turkish journal of pediatrics Vol. 66; no. 4; pp. 412 - 420
• Main Authors: Kurucu, Nilgün, Kutluk, Tezer, Kartal, İbrahim, Yeşil, Şule, Vural, Özge, Dinçer, Oğuz S., Ceyhan, Mehmet
• Format: Journal Article
• Language: English
• Published: 07.10.2024
• ISSN: 0041-4301; 2791-6421
• DOI: 10.24953/turkjpediatr.2024.4512

Background. Children with cancer have a higher morbidity and mortality due to COVID-19. Vaccination of children with cancer is important. In this study, we aimed to investigate the effectiveness and side effects of the COVID-19 vaccines in children and adolescents with cancer. Methods. Fifty-eight patients from four centers were included in the study. Antibodies to the SARS-CoV-2 spike protein levels were measured. Vaccine-related complaints were recorded. Results. There were 33 male and 25 female patients. The mean age was 16.9±2.3 years. In 58.6% of cases, the diagnosis was hematological malignancies. Twenty patients were currently under treatment, while 38 had completed the treatment. Forty-eight patients received chemotherapy ± radiotherapy, 13 received immunotherapy, and 3 underwent stem cell transplantation. CoronoVac© and BNT162b2© vaccines were administered in 24% and 76%, respectively. The mean antibody level was lower in patients who received CoronaVac© than that of BNT162b2©, although the difference was not significant. The levels were within the protective limits in both groups. No significant difference was found in antibody levels according to diagnostic subgroups, treatment status, type of treatment, line of treatment, disease status and time between vaccines and measurement of antibody level. The most common side effects were pain at the injection site (37.9%) and malaise/weakness (17.2%), which were similar for both vaccines. Conclusions. Our study showed that both mRNA and inactivated vaccines elicit an immune response in children with cancer. However, the seroconversion rate is significantly higher in mRNA vaccines. Side effects were similar to those seen in healthy children.