Extracellular vesicles in pulmonary infection: From pathophysiology to theranostic technologies

• Published in: Chemical engineering journal (Lausanne, Switzerland : 1996) Vol. 498; p. 155585
• Main Authors: Wang, Xu, Shi, Mai-Qing, Wang, Yang, Zhou, Hao, Peng, Ke, Wang, Jun, Sun, Shi-Kun, Shen, Xu-Rui, Wang, Jia-Jia, Zhao, Zhi, Ding, Xian-Guang, Ji, Fu-Hai
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 15.10.2024
• Subjects: Extracellular vesicles; Nanomedicine; Nanotechnology; Pulmonary infection; Theranostics; Extracellular vesicles; Nanomedicine; Theranostics; Pulmonary infection; Nanotechnology
• ISSN: 1385-8947
• DOI: 10.1016/j.cej.2024.155585

•Role of EVs in pathogenesis of PI through the transport of proteins, nucleic acids and lipids.•How EVs affect immune responses and contribute to the disseminations of pathogens, imapcting the host cell environment.•Clinical viability of EVs as theranostic targets, including safety profiles and effectiveness in treating PI. Pulmonary infection (PI) poses a significant challenge to global health, exacerbated by the ongoing evolution of respiratory pathogens, increasing antibiotic resistance, and the emergence of novel infectious agents. Extracellular vesicles (EVs), as key mediators of intercellular communication that transport proteins, nucleic acids, and lipids, play a pivotal role in intercellular communication, offering promising avenues to enhance the understanding of pathophysiology and develop innovative diagnostic and therapeutic strategies. This article aims to review recent clinical advances in the application of EVs for PI, emphasizing their mechanistic role in PI progression and their potential as a versatile platform for both diagnostic and therapeutic strategies. Additionally, we would also discuss the challenges associated with translating EV-based innovations from bench to bedside, focusing on bridging pathophysiological discoveries with their theranostic applications. Through this comprehensive overview, we aim to demonstrate the transformative potential of EV technologies in managing PI, highlighting the dynamic interaction between evolving EV technologies and the pressing needs of public health.