Cover Feature: Cyanine‐Flavonol Hybrids for Near‐Infrared Light‐Activated Delivery of Carbon Monoxide (Chem. Eur. J. 58/2020)

Carbon monoxide (CO) is an endogenous signaling molecule with a remarkable therapeutic potential hindered by its inherent toxicity. The cross‐breeding of a CO‐releasing flavonol moiety with a cyanine dye enabled access to the family of CO‐releasing molecules activatable upon irradiation with near‐in...

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Published inChemistry : a European journal Vol. 26; no. 58; p. 13105
Main Authors Štacková, Lenka, Russo, Marina, Muchová, Lucie, Orel, Vojtěch, Vítek, Libor, Štacko, Peter, Klán, Petr
Format Journal Article
LanguageEnglish
Published 15.10.2020
Subjects
CO release
cyanine
near-infrared light
photoCORM
photorelease
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Summary:Carbon monoxide (CO) is an endogenous signaling molecule with a remarkable therapeutic potential hindered by its inherent toxicity. The cross‐breeding of a CO‐releasing flavonol moiety with a cyanine dye enabled access to the family of CO‐releasing molecules activatable upon irradiation with near‐infrared light up to 820 nm. These hybrids liberate two molecules of CO with efficiencies surpassing those of the state‐of‐the‐art systems by two orders of magnitude. The biocompatibility and applicability of this system were showcased both in vitro and in vivo. The cover image was created by Lenka Štacková, Peter Štacko, and Orazio Angelo Arcidiacono. More information can be found in the Full Paper by P. Štacko, P. Klán, et al. on page 13184.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202004017