Massive anterior chamber involvement in advanced retinoblastoma following intra‐arterial chemotherapy

Purpose to describe retinoblastoma massive anterior chamber involvement after treatment with intra‐arterial chemotherapy. This condition represents an extremely poor prognostic sign for ocular preservation in patients with retinoblastoma. Therefore, anterior chamber retinoblastoma should be consider...

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Published inActa ophthalmologica (Oxford, England) Vol. 90; no. s249
Main Authors DE FRANCESCO, S, MASTRANGELO, D, DE LUCA, MC, MENICACCI, F, TOTI, P, MICHELI, L, HADJISTILIANOU, T
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.09.2012
Wiley Subscription Services, Inc
Subjects
Chemotherapy
Ophthalmology
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Summary:Purpose to describe retinoblastoma massive anterior chamber involvement after treatment with intra‐arterial chemotherapy. This condition represents an extremely poor prognostic sign for ocular preservation in patients with retinoblastoma. Therefore, anterior chamber retinoblastoma should be considered an absolute indication for enucleation. Methods Ultrasound biomicroscopy (UBM) was used to document tumour pseudohypopion, cells in the aqueous humor, implanted clusters of cells on the corneal endothelium, iris nodules and lens capsule deposits. Results The UBM data were compared with the histopathologic analysis after enucleation and revealed a significant concordance. Conclusion UBM may represent an important diagnostic tool in retinoblastoma, particularly when the decision about enucleation of the eye, must be made in the absence of histopathologic data.
ISSN:1755-375X
1755-3768
DOI:10.1111/j.1755-3768.2012.S017.x