Cover Feature: Application of Neuron‐Selective Fluorescent Probe, NeuA, To Identify Mouse Retinal Degeneration (ChemBioChem 11/2021)

The newly developed NeuA stains live neurons, such as photoreceptor cells in the retina. The cover feature picture shows the NeuA‐stained retina in the cross cryosection after tail vein injection. NeuA highly stains the outer segment layer and cell bodies of photoreceptor cells and some bipolar cell...

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Published inChembiochem : a European journal of chemical biology Vol. 22; no. 11; p. 1853
Main Authors Park, Sung‐Jin, Woon, Queenie Tan Shu, Er, Jun Cheng, Wong, Bernice H., Liu, Xiao, Kang, Nam‐Young, Barathi, Veluchamy A., Silver, David L., Chang, Young‐Tae
Format Journal Article
LanguageEnglish
Published 02.06.2021
Subjects
fluorescent probe
NeuA
outer segment of photoreceptors
retinal application
retinal degeneration
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Summary:The newly developed NeuA stains live neurons, such as photoreceptor cells in the retina. The cover feature picture shows the NeuA‐stained retina in the cross cryosection after tail vein injection. NeuA highly stains the outer segment layer and cell bodies of photoreceptor cells and some bipolar cells (green). Nuclei were stained with DAPI (blue). With this characteristic, this study demonstrated that NeuA distinguishes between healthy and photoreceptor degenerate retinas as an in vivo application. More information can be found in the Communication by D. L. Silver, Y.‐T. Chang et al.
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.202100206