Cover Feature: Profiling Heparan Sulfate‐Heavy Metal Ions Interaction Using Electrochemical Techniques (Chem. Eur. J. 55/2022)

The connection between heparan sulfate molecular components and heavy metal ion binding is largely unknown because of the complexity and the heterogeneity of the polysaccharide, which limit the ability to study those interactions. By assembling rationally designed synthetic heparan sulfates on surfa...

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Published inChemistry : a European journal Vol. 28; no. 55
Main Authors Shitrit, Ariel, Mardhekar, Sandhya, Alshanski, Israel, Jain, Prashant, Raigawali, Rakesh, Shanthamurthy, Chethan D., Kikkeri, Raghavendra, Yitzchaik, Shlomo, Hurevich, Mattan
Format Journal Article
LanguageEnglish
Published 04.10.2022
Subjects
carbohydrates
electrochemistry
heavy metal ions
sulfation pattern
surface chemistry • uronic acid
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Summary:The connection between heparan sulfate molecular components and heavy metal ion binding is largely unknown because of the complexity and the heterogeneity of the polysaccharide, which limit the ability to study those interactions. By assembling rationally designed synthetic heparan sulfates on surfaces, we have developed new ways to correlate glycan stereochemistry and sulfate group regiochemistry with heavy metal ion binding and selectivity. More information can be found in the Research Article by R. Kikkeri, S. Yitzchaik, M. Hurevich, and co‐workers (DOI: 10.1002/chem.202202193).
Bibliography:These authors contributed equally to this work.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202202805