Back Cover: The Beneficial Effects of Apical Sodium‐Dependent Bile Acid Transporter Inactivation Depend on Dietary Fat Composition

Mol. Nutr. Food Res. 2020, 64, 2000750 DOI: 10.1002/mnfr.202000750 Inactivation of the apical sodium bile acid transporter (ASBT) interrupts the enterohepatic circulation of bile acids and subsequently impairs lipid absorption. Asbt−/− mice are protected from obesity, insulin resistance and fatty li...

Full description

Saved in:
Bibliographic Details
Published inMolecular nutrition & food research Vol. 64; no. 24
Main Authors Peppel, Ivo P., Rao, Anuradha, Dommerholt, Marleen B., Bongiovanni, Laura, Thomas, Rachel, Bruin, Alain, Karpen, Saul J., Dawson, Paul A., Verkade, Henkjan J., Jonker, Johan W.
Format Journal Article
LanguageEnglish
Published 01.12.2020
Online AccessGet full text

Cover

More Information
Summary:Mol. Nutr. Food Res. 2020, 64, 2000750 DOI: 10.1002/mnfr.202000750 Inactivation of the apical sodium bile acid transporter (ASBT) interrupts the enterohepatic circulation of bile acids and subsequently impairs lipid absorption. Asbt−/− mice are protected from obesity, insulin resistance and fatty liver disease when fed a high‐fat diet rich in saturated but not polyunsaturated fatty acids, highlighting the importance of dietary composition in assessment of treatments targeting bile acid homeostasis. This is reported by Ivo P. van de Peppel, Anuradha Rao, Marleen B. Dommerholt, Laura Bongiovanni, Rachel Thomas, Alain de Bruin, Saul J. Karpen, Paul A. Dawson, Henkjan J. Verkade, Johan W. Jonker in article number 2000750.
ISSN:1613-4125
1613-4133
DOI:10.1002/mnfr.202070055