Front Cover: One Way Traffic: Base‐to‐Backbone Hole Transfer in Nucleoside Phosphorodithioate (Chem. Eur. J. 43/2020)

The direction of hole transfer (unpaired spin) in the DNA‐component, occurring between base and modified phosphate, is depicted in the cover artwork. This process critically determines the DNA‐backbone damage. In one‐electron oxidized phosphorodithioate nucleotide, the hole is initially localized on...

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Bibliographic Details
Published inChemistry : a European journal Vol. 26; no. 43; p. 9403
Main Authors Kaczmarek, Renata, Ward, Samuel, Debnath, Dipra, Jacobs, Taisiya, Stark, Alexander D., Korczyński, Dariusz, Kumar, Anil, Sevilla, Michael D., Denisov, Sergey A., Shcherbakov, Viacheslav, Pernot, Pascal, Mostafavi, Mehran, Dembinski, Roman, Adhikary, Amitava
Format Journal Article
LanguageEnglish
Published 03.08.2020
Subjects
DNA damage
hole transfer
radiation chemistry
radical ions
radicals
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Summary:The direction of hole transfer (unpaired spin) in the DNA‐component, occurring between base and modified phosphate, is depicted in the cover artwork. This process critically determines the DNA‐backbone damage. In one‐electron oxidized phosphorodithioate nucleotide, the hole is initially localized on guanine base as a cation radical (Gua.+). Next, via base‐to‐backbone hole transfer, the hole appears on phosphorodithioate as dithiyl radical. Cover art designed by Ariela Kaspi‐Kaneti, with contribution from Aditya Paul. More information can be found in the Full Paper by R. Dembinski, A. Adhikary, et al. on page 9495.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.202002714