Cover Feature: α‐Helix‐Mimetic Foldamers for Targeting HIV‐1 TAR RNA (Chem. Eur. J. 30/2019)

An α‐helical synthetic protein mimetic strategy has been employed to disrupt the HIV TAR RNA‐TAT assembly, which is a prerequisite for the proliferation of HIV virus. The cover picture demonstrates specific targeting of TAR RNA by an oligopyridylamide, which consequently attenuates the effect of HIV...

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Bibliographic Details
Published inChemistry : a European journal Vol. 25; no. 30; p. 7230
Main Authors Maity, Debabrata, Kumar, Sunil, Curreli, Francesca, Debnath, Asim K., Hamilton, Andrew D.
Format Journal Article
LanguageEnglish
Published 28.05.2019
Subjects
anti-HIV
foldamers
oligopyridylamides
peptidomimetics
RNA recognition
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Summary:An α‐helical synthetic protein mimetic strategy has been employed to disrupt the HIV TAR RNA‐TAT assembly, which is a prerequisite for the proliferation of HIV virus. The cover picture demonstrates specific targeting of TAR RNA by an oligopyridylamide, which consequently attenuates the effect of HIV on the host cells. This approach is versatile and convenient, owing to the breadth of surface functionalities that could mimic numerous protein surfaces, and has the potential to be applied to a wide range of RNA–protein interactions that are associated with many diseases. More information can be found in the Communication by S. Kumar, A. D. Hamilton, et al. on page 7265.
Bibliography:These authors contributed equally to this work.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201901752