Front Cover: Generic reversed‐phase ultra‐high‐pressure liquid chromatography methodology developed by using computer‐assisted modeling for streamlined performance evaluation of a wide range of stationary phase columns
DOI: 10.1002/sscp.202200002 A generic probe methodology was developed using in silico chromatography modeling tools. The separation of a standard multicomponent mixture was optimized on multiple columns/mobile phases. An optimal space across the overlay of different resolution maps is identified and...
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| Published in | Separation science plus Vol. 5; no. 5 |
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| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
01.05.2022
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| Online Access | Get full text |
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| Abstract | DOI: 10.1002/sscp.202200002
A generic probe methodology was developed using in silico chromatography modeling tools. The separation of a standard multicomponent mixture was optimized on multiple columns/mobile phases. An optimal space across the overlay of different resolution maps is identified and used as a generic probe condition under which the components of the standard mixture will be resolved on all columns/mobile phases combinations. The resulting generic probe is used as a framework for testing column robustness and stability to ensure a straightforward method development and transfer workflow. |
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| AbstractList | DOI: 10.1002/sscp.202200002
A generic probe methodology was developed using in silico chromatography modeling tools. The separation of a standard multicomponent mixture was optimized on multiple columns/mobile phases. An optimal space across the overlay of different resolution maps is identified and used as a generic probe condition under which the components of the standard mixture will be resolved on all columns/mobile phases combinations. The resulting generic probe is used as a framework for testing column robustness and stability to ensure a straightforward method development and transfer workflow. |
| Author | Korani, Deepa Hartman, Robert Hamilton, Simon Regalado, Erik L. Hullen, Kari Losacco, Gioacchino Luca Gunsch, Matthew J. Lhotka, Hayley R. Mangion, Ian Ahmad, Imad A. Haidar Figus, Margaret Lohani, Sachin |
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A generic probe methodology was developed using in silico chromatography modeling tools. The separation of a standard... |
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| Title | Front Cover: Generic reversed‐phase ultra‐high‐pressure liquid chromatography methodology developed by using computer‐assisted modeling for streamlined performance evaluation of a wide range of stationary phase columns |
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