Front Cover: Generic reversed‐phase ultra‐high‐pressure liquid chromatography methodology developed by using computer‐assisted modeling for streamlined performance evaluation of a wide range of stationary phase columns

DOI: 10.1002/sscp.202200002 A generic probe methodology was developed using in silico chromatography modeling tools. The separation of a standard multicomponent mixture was optimized on multiple columns/mobile phases. An optimal space across the overlay of different resolution maps is identified and...

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Published inSeparation science plus Vol. 5; no. 5
Main Authors Ahmad, Imad A. Haidar, Losacco, Gioacchino Luca, Figus, Margaret, Korani, Deepa, Gunsch, Matthew J., Lhotka, Hayley R., Hullen, Kari, Hartman, Robert, Lohani, Sachin, Hamilton, Simon, Mangion, Ian, Regalado, Erik L.
Format Journal Article
LanguageEnglish
Published 01.05.2022
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Summary:DOI: 10.1002/sscp.202200002 A generic probe methodology was developed using in silico chromatography modeling tools. The separation of a standard multicomponent mixture was optimized on multiple columns/mobile phases. An optimal space across the overlay of different resolution maps is identified and used as a generic probe condition under which the components of the standard mixture will be resolved on all columns/mobile phases combinations. The resulting generic probe is used as a framework for testing column robustness and stability to ensure a straightforward method development and transfer workflow.
ISSN:2573-1815
2573-1815
DOI:10.1002/sscp.202270031