Cover Feature: Methionine Capped Nanoparticles as Acetylcholinesterase Inhibitors (Eur. J. Inorg. Chem. 12/2023)

The Cover Feature shows a metal nanoparticle modified with the amino acid L‐methionine and the adsorption of the enzyme acetylcholinesterase (AChE) on the methionine‐capped nanoparticle surface. Methionine‐capped Ag and Au nanoparticles (NPs) were tested as inhibitors of AChE, and they showed modera...

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Bibliographic Details
Published inEuropean journal of inorganic chemistry Vol. 26; no. 12
Main Authors Laban, Bojana B., Lazarević‐Pašti, Tamara, Veljović, Djordje, Marković, Mirjana, Klekotka, Urszula
Format Journal Article
LanguageEnglish
Published 25.04.2023
Subjects
acetylcholinesterase
alzheimer‘s disease
gold
inhibition
nanoparticles
silver
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Summary:The Cover Feature shows a metal nanoparticle modified with the amino acid L‐methionine and the adsorption of the enzyme acetylcholinesterase (AChE) on the methionine‐capped nanoparticle surface. Methionine‐capped Ag and Au nanoparticles (NPs) were tested as inhibitors of AChE, and they showed moderate inhibitory potential toward AChE. NPs are much larger than enzyme molecules and cannot enter the active site gorge, so inhibition occurs by blockage of the enzyme's active site due to the adsorption of AChE on the surface of the NPs. Ag and Au methionine‐capped NPs have the potential to be further investigated for use in the treatment of cognitive impairment accompanying depression and Alzheimer's disease. We want to thank Prof. Igor Pašti for the graphic design. More information can be found in the Research Article by B. B. Laban and co‐workers.
ISSN:1434-1948
1099-0682
DOI:10.1002/ejic.202300151