Organ‐on‐a‐Chip: A Heart‐Breast Cancer‐on‐a‐Chip Platform for Disease Modeling and Monitoring of Cardiotoxicity Induced by Cancer Chemotherapy (Small 15/2021)

In article number 2004258, Ali Khademhosseini, Su Ryon Shin, and co‐workers develop a model for investigating chemotherapy‐induced cardiotoxicity where induced pluripotent stem cell‐derived cardiac tissues are interacted with breast cancer tissues on a dual‐organ platform. Using electrochemical immu...

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Published inSmall (Weinheim an der Bergstrasse, Germany) Vol. 17; no. 15
Main Authors Lee, Junmin, Mehrotra, Shreya, Zare‐Eelanjegh, Elaheh, Rodrigues, Raquel O., Akbarinejad, Alireza, Ge, David, Amato, Luca, Kiaee, Kiavash, Fang, YongCong, Rosenkranz, Aliza, Keung, Wendy, Mandal, Biman B., Li, Ronald A., Zhang, Ting, Lee, HeaYeon, Dokmeci, Mehmet Remzi, Zhang, Yu Shrike, Khademhosseini, Ali, Shin, Su Ryon
Format Journal Article
LanguageEnglish
Published 15.04.2021
Subjects
breast cancer
cardiotoxicity
electrochemical biosensors
iPSC‐cardiac tissues
organs‐on‐a‐chip
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Summary:In article number 2004258, Ali Khademhosseini, Su Ryon Shin, and co‐workers develop a model for investigating chemotherapy‐induced cardiotoxicity where induced pluripotent stem cell‐derived cardiac tissues are interacted with breast cancer tissues on a dual‐organ platform. Using electrochemical immuno‐aptasensors to monitor cell‐secreted multiple biomarkers, the proposed platform could be potentially suitable for early detection and prediction of cardiotoxicity in individual patients.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.202170070