Cover Feature: Synthesis and Assessment of Fused β‐Carboline Derivatives as Kappa Opioid Receptor Agonists (12/2021)

The Cover Feature shows a new β‐carboline derivative having significant biased KOR agonist activity, which was experimentally shown to have analgesic effect without sedation (represented in cyan). The brownish red cartoon symbolizes the subject in agony due to pain. The dosing of the compound reliev...

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Published inChemMedChem Vol. 16; no. 12; p. 1834
Main Authors Yadav, Veena D., Kumar, Lalan, Kumari, Poonam, Kumar, Sakesh, Singh, Maninder, Siddiqi, Mohammad I., Yadav, Prem N., Batra, Sanjay
Format Journal Article
LanguageEnglish
Published 17.06.2021
Subjects
beta-carboline
kappa opioid receptor agonist
molecular modeling
nitrogen heterocycle
pain
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Summary:The Cover Feature shows a new β‐carboline derivative having significant biased KOR agonist activity, which was experimentally shown to have analgesic effect without sedation (represented in cyan). The brownish red cartoon symbolizes the subject in agony due to pain. The dosing of the compound relieves the pain, making the subject active and happy without any side effects. A tentative binding of the compound in the hKOR is also depicted. Cover design by Maninder Singh and Prem N. Yadav. More information can be found in the Full Paper by Sanjay Batra et al.
Bibliography:These authors contributed equally to this work.
ISSN:1860-7179
1860-7187
DOI:10.1002/cmdc.202100380