Fabrication and Character Study of the Anticancer Drug Paclitaxel (Taxol): PLGA nanoparticles-The benefaction for the modern therapeutic area

• Published in: Research journal of pharmacy and technology Vol. 13; no. 1; pp. 265 - 269
• Main Author: Umamahesvari, H.
• Format: Journal Article
• Language: English
• Published: Raipur A&V Publications 2020
• Subjects: Bioavailability; Cancer; Drugs; Fourier transforms; Nanoparticles; Particle size; Polylactic acid; Polymers; Spectrum analysis
• ISSN: 0974-3618; 0974-360X; 0974-306X
• DOI: 10.5958/0974-360X.2020.00054.2

Like many other anticancer drugs, there are difficulties in its clinical governance due to its poor solubility. [...]an agitator called Cremophor EL has to be supplemented, but the consequence is serious side-effects. Nanoparticles have attracted widespread attention in international level due to their unique functional characters along with small particle length, high stability, decrease in toxicity, tuneable hydrophilic-hydrophobic balance and the potential to to bear surface features for goal the localization, and many others. [...]polymeric nanoparticles represent a flexible drug transport system [4]. [...]nanoparticles can enhance the bioavailability of poorly absorbed medicine, accordingly enhancing oral transport [7,11]. [...]the nanoparticles are able to permeate cells for cell internalisation and connective tissue permeation and so deliver the drug successfully to the targeted tissue without clogging capillaries [11,12]. Fourier Transform Infrared Spectroscopy (FTIR) Studies: FTIR spectra were taken on to investigate the possible drug-excipient interactions.