A Review on Current Applications of Bilayer Tablets

Both drugs are sustained release. Because of Metformin Hydrochloride is a highly water-soluble drug with high dose (500 mg), there leads to difficulty in providing an extended release rate from formulation and there might be problems in controlling the initial burst of drug from such formulation. [....

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Published inResearch journal of pharmacy and technology Vol. 12; no. 5; pp. 2539 - 2544
Main Authors Joseph, Dhanish, Thomas, Golda Maria
Format Journal Article
LanguageEnglish
Published Raipur A&V Publications 01.05.2019
Subjects
Cellulose
Drug dosages
Glucose
Hypertension
Ingredients
Pharmaceutical industry
Pharmaceutical sciences
Polymers
Sodium
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Summary:Both drugs are sustained release. Because of Metformin Hydrochloride is a highly water-soluble drug with high dose (500 mg), there leads to difficulty in providing an extended release rate from formulation and there might be problems in controlling the initial burst of drug from such formulation. [...]both the drugs show incompatibility with each other, and there arises a need to develop such a system to avoid intimate contact between the two drugs, i.e. sustained release bilayer tablet formulation of Glipizide& Metformin HCl using various polymers such as Hydroxyl Propyl Methyl Cellulose K15 M, Hydroxy Ethyl Cellulose and Ethylcellulose at different concentration15. From the results, Bilayer tablet showed an initial burst effect to provide a dose of immediate release layer Telmisartan to control the blood pressure level and the sustained release of Metformin HCl, for 10 hours, to control the blood glucose level. [...]they were formulated as sustained release matrix tablets.
ISSN:0974-3618
0974-360X
0974-306X
DOI:10.5958/0974-360X.2019.00427.X