The vitamin D neuroendocrine system as a target for novel neurotropic drugs

Vitamin D is a seco-steroid hormone with multiple functions in the nervous system. Physiological brain mechanisms of vitamin D and its receptors include neuroprotection, antiepileptic effects, immunomodulation, possible interplay with several brain neurotransmitter systems and hormones, as well as t...

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Bibliographic Details
Published inCNS & neurological disorders drug targets Vol. 5; no. 3; p. 363
Main Authors Kalueff, A V, Minasyan, A, Keisala, T, Kuuslahti, M, Miettinen, S, Tuohimaa, P
Format Journal Article
LanguageEnglish
Published United Arab Emirates 01.06.2006
Subjects
Animals
Central Nervous System Agents - administration & dosage
Drug Delivery Systems - methods
Drugs, Investigational - administration & dosage
Humans
Neurosecretory Systems - drug effects
Neurosecretory Systems - physiology
Vitamin D - administration & dosage
Vitamin D - physiology
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Summary:Vitamin D is a seco-steroid hormone with multiple functions in the nervous system. Physiological brain mechanisms of vitamin D and its receptors include neuroprotection, antiepileptic effects, immunomodulation, possible interplay with several brain neurotransmitter systems and hormones, as well as the regulation of behaviours. Here we review the important role of the vitamin D neuroendocrine system in the brain, and outline perspectives for the search for novel neurotropic drugs to treat various vitamin D-related dysfunctions.
ISSN:1871-5273
DOI:10.2174/187152706777452209