P247 MR enterography in Crohn’s disease: Comparison between diffusion-weighted imaging and intravenous contrast material in detection of active disease

• Published in: Journal of Crohn's and colitis Vol. 12; no. supplement_1; p. S225
• Main Authors: Geccherle, A, Variola, A, Massella, A, Demozzi, E, Oliboni, E, Carbognin, G, Romano, L
• Format: Journal Article
• Language: English
• Published: UK Oxford University Press 16.01.2018
• ISSN: 1873-9946; 1876-4479
• DOI: 10.1093/ecco-jcc/jjx180.374

Abstract Background MR is a crucial diagnostic tool for Crohn’s disease (CD). The aim of the study was to determine the performance of diffusion-weighted imaging magnetic resonance enterography (DWI-MRE) compared with contrast material-enhanced MR enterography (CE-MRE) for evaluating bowel inflammation activity in CD. Methods We retrospectively review 55 consecutive adults patients with CD that underwent clinical assessment, MR enterography, and ileocolonoscopy within 4 weeks. Inclusion criteria were: a) DWI-MRE with the following b values (50, 400 and 800 s/mm2) and CE-MRE and b) histologically examination after colonoscopy. The final study population included 39 patients (19 M, 20 F, mean age 42 years). The results were compared with the histo-pathological examination after colonoscopy as the reference standard. The sensitivity (se), specificity (sp), positive predicting value (PPV), negative predicting value (NPV) and accuracy (acc) of DWI and CE-MR enterography in distinguishing active inflammatory lesions from inactive lesions were deter- mined. Results DWI yielded se, sp, PPV, NPV and acc of 88%, 82%, 91%, 75% and 86%, respectively, in distinguishing active inflammatory lesions from inactive lesions. Conversely, se, sp, PPV, NPV and acc obtained using CE-MR were 88%, 64%, 84%, 70% and 80%, respectively. Conclusions DWI-MR enterography was superior to CE-MR enterography for the evaluation of inflammation in Crohn disease, and could be considered as a potential biomarker of active inflammation in CD.