Determination of levels of carcinoembryonic antigen and nonspecific cross-reacting antigen in the sera of neonatal infants: brief communication

Seventy-eight sera from neonatal infants, born at full term or prematurely, were studied for their carcinoembryonic antigen (CEA) and nonspecific cross-reacting antigen (NCA) concentrations, which were compared to the normal adult concentrations. The levels of CEA in the sera were significantly high...

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Bibliographic Details
Published inJNCI : Journal of the National Cancer Institute Vol. 59; no. 6; p. 1621
Main Authors von Kleist, S, Troupel, S, King, M, Burtin, P
Format Journal Article
LanguageEnglish
Published United States 01.12.1977
Subjects
Adult
alpha-Fetoproteins - analysis
Antigens - analysis
Carcinoembryonic Antigen - analysis
Cross Reactions
Female
Humans
Infant, Newborn
Infant, Premature
Male
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Summary:Seventy-eight sera from neonatal infants, born at full term or prematurely, were studied for their carcinoembryonic antigen (CEA) and nonspecific cross-reacting antigen (NCA) concentrations, which were compared to the normal adult concentrations. The levels of CEA in the sera were significantly higher in newborns than in adults: 9.05 ng CEA/ml in newborns as compared to 2.5 ng CEA/ml in adults (P=0.001). The levels of NCA in the sera were also higher in newborns: 164 ng NCA/ml in newborns as compared to 130 ng NCA/ml in adults. This difference in NCA levels was not significant, although 80% of the newborns had increased values (greater than 130 ng/ml). Whether the infant was born at full term or prematurely and whether the infant was a boy or girl had no statistically significant influence on the concentration of the CEA and the NCA in the infant.
ISSN:0027-8874
1460-2105
DOI:10.1093/jnci/59.6.1621