novel insights into neuronal and vascular damage glaucoma

Despite decades of clinical and basic research, we still do not understand the factors that cause retinal ganglion cell death and loss of vision in glaucoma patients. This keynote lecture will provide insights into new mechanisms that lead to early neuronal and neurovascular dysregulation in glaucom...

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Bibliographic Details
Published inActa ophthalmologica (Oxford, England) Vol. 100; no. S275
Main Author Di Polo, Adriana
Format Journal Article
LanguageEnglish
Published Malden Wiley Subscription Services, Inc 01.12.2022
Subjects
Cell death
Cell viability
Glaucoma
Nanotubes
Optic neuropathy
Pericytes
Recovery of function
Retina
Visual perception
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Summary:Despite decades of clinical and basic research, we still do not understand the factors that cause retinal ganglion cell death and loss of vision in glaucoma patients. This keynote lecture will provide insights into new mechanisms that lead to early neuronal and neurovascular dysregulation in glaucoma. Several pathological changes associated with retinal ganglion cell damage will be discussed including dendritic retraction and synapse loss, metabolic deficits, and loss of neurovascular coupling. The role of pericytes in retinal capillary function will be presented, including newly identified inter‐pericyte tunnelling nanotubes, and their impact on retinal ganglion cell viability. These new data will highlight therapeutic opportunities to alleviate key pathological processes and restore visual function in glaucoma and other optic neuropathies.
ISSN:1755-375X
1755-3768
DOI:10.1111/j.1755-3768.2022.15622