Incorporation of 4,5-3H leucine into the neurons of locus ceruleus and other nerve cells in stressed rats: effect of diazepam

Incorporation of 4,5-3H leucine into neurons of locus ceruleus, neurons of the terminal principal nucleus of the trigeminal nerve and spinal moto-neurons in stressed rats (S group), animals, stressed after a single injection of diazepam (DS group), and controls (C group) was studied by quantitative...

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Bibliographic Details
Published inPsychopharmacology Vol. 50; no. 2; p. 193
Main Authors Jakoubek, B, Petrovický, P
Format Journal Article
LanguageEnglish
Published Germany 10.11.1976
Subjects
Animals
Autoradiography
Cerebral Ventricles - metabolism
Diazepam - pharmacology
Humans
Male
Motor Neurons - metabolism
Nerve Tissue Proteins - biosynthesis
Neurons - metabolism
Rats
Spinal Cord - metabolism
Stress, Psychological
Trigeminal Nerve - metabolism
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Summary:Incorporation of 4,5-3H leucine into neurons of locus ceruleus, neurons of the terminal principal nucleus of the trigeminal nerve and spinal moto-neurons in stressed rats (S group), animals, stressed after a single injection of diazepam (DS group), and controls (C group) was studied by quantitative autoradiography. Both in the S and DS groups the planimetrically measured neuronal areas were bigger than in the C group of spinal motoneurons and trigeminal neurons. Stress, however, had no effect on the size of neurons in locus ceruleus. No significant differences of grain density among C and S group were found in the three investigated neuronal groups; diazepam pretreatment (DS group), however, increased markedly the grain density in all types of neurons investigated.
ISSN:0033-3158
1432-2072
DOI:10.1007/BF00430492