ChemInform Abstract: 1-(1-Acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a Potent, Selective, and Orally Available Soluble Epoxide Hydrolase Inhibitor with Efficacy in Rodent Models of Hypertension and Dysglycemia

The synthesis of the clinical candidate (I) and its analogues is achieved via a library approach allowing the facile preparation of various left hand side and right hand side combinations around the piperidinyl urea nucleus.

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Bibliographic Details
Published inChemInform Vol. 42; no. 28; p. no
Main Authors Anandan, Sampath-Kumar, ., et al
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 12.07.2011
WILEY‐VCH Verlag
Subjects
enzyme inhibiting activity
pyridine derivatives
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Summary:The synthesis of the clinical candidate (I) and its analogues is achieved via a library approach allowing the facile preparation of various left hand side and right hand side combinations around the piperidinyl urea nucleus.
Bibliography:ArticleID:CHIN201128147
istex:E0EF929020CB79D8A6DFE27D867EEB04FE1D9169
ark:/67375/WNG-TDPXQ5TK-C
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201128147