STRUCTURAL AND FUNCTIONAL CHANGES IN BONE TISSUE OF THE SPINE AND EXTREMITIES IN OXYS RATS

• Published in: Khirurgii︠a︡ pozvonochnika = Spine surgery no. 1; pp. 88 - 94
• Main Authors: Falameeva, Olga Viktorovna, Sadovoy, Mikhail Anatolyevich, Khrapova, Yulia Viktorovna, Kolosova, Natalya Gorislavovna
• Format: Journal Article
• Language: English
• Published: 12.04.2006
• ISSN: 1810-8997; 2313-1497
• DOI: 10.14531/ss2006.1.88-94

Objective. To study specific structural and functional changes in bone tissue in Oxys rats of different age. Material and Methods. Mineral density of bone tissue in Oxys and Wistar male rats at the age of 2–18 months was examined with x-ray bone densitometer LUNAR-Exert-XL (USA). Bone fragments of vertebral bodies and of forelegs and hind legs were studied by histomorphometric assay with software Motic Images Plus 2.0 ML (Micromed, Russia). Results. X-ray bone densitometry findings have shown that bone mineral density increase in Oxys rats does not attain the values shown by age-matched control rats, and progressively decreases after the age of 6 months. Data obtained by histomorphometric analysis of vertebral bodies and limbs have reliably demonstrated that there is a change in quantitative and qualitative bone tissue parameters of Oxys rats which is a characteristic of osteoporosis. Conclusion. Bone tissue changes in Oxys rats correspond to that observed in human osteoporosis, what allows to use rat as a model for the study of osteoporosis pathogenesis and for development of prophylaxis and treatment methods.