ChemInform Abstract: Expeditious One-Pot, Four-Step Preparation of 2-t-Butoxycarbonyl-6-hydroxy-1,2,3,4-tetrahydroisoquinoline and an Improved Conversion to Its 6-Cyano Derivative

Title compound (IV) is obtained in multigram quantities by a novel sequential one‐pot procedure comprising imination/Pictet—Spengler cyclization/demethylation/Boc‐protection.

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Bibliographic Details
Published inChemInform Vol. 41; no. 40; p. no
Main Authors Gordon, David W., Bains, Carol A.
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 05.10.2010
WILEY‐VCH Verlag
Subjects
cyanation
cyanation, nitrile formation
isoquinoline derivatives
nitrile formation
ring closure reactions
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Summary:Title compound (IV) is obtained in multigram quantities by a novel sequential one‐pot procedure comprising imination/Pictet—Spengler cyclization/demethylation/Boc‐protection.
Bibliography:ArticleID:CHIN201040154
ark:/67375/WNG-PJ5F416N-2
istex:469EFE5656E0D8A5A48F0C37F05AE4C9E6E25F27
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201040154