ChemInform Abstract: Synthesis and Biological Evaluation of Dialkylaminoalkylamino Benzo[c][1,7] and [1,8]Phenanthrolines as Antiproliferative Agents

• Published in: ChemInform Vol. 41; no. 41; p. no
• Main Authors: Serbetci, Tuba, Genes, Constance, Depauw, Sabine, Prado, Soizic, Poree, Francois-Hugues, Hildebrand, Marie-Paule, David-Cordonnier, Marie-Helene, Michel, Sylvie, Tillequin, Francois
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 12.10.2010; WILEY‐VCH Verlag
• Subjects: anticancer activity; anticarcinogenic activity; anticarcinogenic activity, anticancer activity; fused pyridine derivatives

Title compounds (IV) as well as its [1,8]‐regioisomers display more potent cytotoxicity toward L1210 cells than the unsubstituted parent compounds, associated with strong DNA interaction.