ChemInform Abstract: Synthesis and Biological Evaluation of Dialkylaminoalkylamino Benzo[c][1,7] and [1,8]Phenanthrolines as Antiproliferative Agents

Title compounds (IV) as well as its [1,8]‐regioisomers display more potent cytotoxicity toward L1210 cells than the unsubstituted parent compounds, associated with strong DNA interaction.

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Bibliographic Details
Published inChemInform Vol. 41; no. 41; p. no
Main Authors Serbetci, Tuba, Genes, Constance, Depauw, Sabine, Prado, Soizic, Poree, Francois-Hugues, Hildebrand, Marie-Paule, David-Cordonnier, Marie-Helene, Michel, Sylvie, Tillequin, Francois
Format Journal Article
LanguageEnglish
Published Weinheim WILEY-VCH Verlag 12.10.2010
WILEY‐VCH Verlag
Subjects
anticancer activity
anticarcinogenic activity
anticarcinogenic activity, anticancer activity
fused pyridine derivatives
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Summary:Title compounds (IV) as well as its [1,8]‐regioisomers display more potent cytotoxicity toward L1210 cells than the unsubstituted parent compounds, associated with strong DNA interaction.
Bibliography:istex:05FCDE02A647E28E2964EA7F410979A8AE6941AF
ArticleID:CHIN201041143
ark:/67375/WNG-S3HM77XS-X
ISSN:0931-7597
1522-2667
DOI:10.1002/chin.201041143